Dee Wallace Spencer, a principal lecturer at Northeastern University, is running for the open seat in the 1st Plymouth House district.
Wallace Spencer, who is a lifelong Plymouth resident, made the announcement Thursday at a campaign kickoff at the ThreeV restaurant at Cordage Park.
She is the only Republican in the race so far.
On the Democratic side, three candidates have announced: retired Citibank executive Arthur Desloges, Plymouth School Committee member Michelle Badger, and businessman Scott Hokanson. The primary is Sep. 3.
The seat is open because State Rep. Mathew Muratore, a Republican, is running for the state Senate.
The district includes all of Plymouth except for downtown and North Plymouth, which are in the 12th Plymouth district represented by Kingston Democrat Kathleen LaNatra.
Wallace Spencer said in a statement that if elected her priorities would include a focus on making Massachusetts more affordable and providing support for first responders.
The daughter of Tom Wallace, one of the original proponents of the Pinehills development, Wallace Spencer co-authored the Open Space Mixed Use Development bylaw that governs the development of the planned community.
Fred Thys can be reached at fred@plymouthindependent.org